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KMID : 0578320210440100736
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Molecules and Cells
2021 Volume.44 No. 10 p.736 ~ p.745
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Extracellular Vesicles from Korean Codium fragile and Sargassum fusiforme Negatively Regulate Melanin Synthesis
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Jang Bo-Hee
Chung Hee-Sung
Jung Hye-Jung
Song Hyun-Kuk
Park Eun-Hye
Choi Hack-Sun
Jung Kyu-Hyun
Choe Han
Yang Sang-Hwa
Oh Eok-Soo
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Abstract
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Although various marine ingredients have been exploited for the development of cosmetic products, no previous study has examined the potential of seaweed extracellular vesicles (EV) in such applications. Our results revealed that EV from Codium fragile and Sargassum fusiforme effectively decreased α-MSH-mediated melanin synthesis in MNT-1 human melanoma cells, associated with downregulation of MITF (microphthalmia-associated transcription factor), tyrosinase and TRP1 (tyrosinase-related proteins 1). The most effective inhibitory concentrations of EV were 250 μg/ml for S. fusiforme and 25 μg/ml for C. fragile, without affecting the viability of MNT-1 cells. Both EV reduced melanin synthesis in the epidermal basal layer of a three-dimensional model of human epidermis. Moreover, the application of the prototype cream containing C. fragile EV (final 5 μg/ml) yielded 1.31% improvement in skin brightness in a clinical trial. Together, these results suggest that EV from C. fragile and S. fusiforme reduce melanin synthesis and may be potential therapeutic and/or supplementary whitening agents.
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KEYWORD
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extracellular vesicles, melanin synthesis, seaweed, skin epidermis
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