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KMID : 0578320220450080550
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Molecules and Cells
2022 Volume.45 No. 8 p.550 ~ p.563
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Downregulation of SETD5 Suppresses the Tumorigenicity of Hepatocellular Carcinoma Cells
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Park Mi-Jin
Moon Byul
Kim Jong-Hwan
Park Seung-Jin
Kim Seon-Kyu
Park Ki-Hyun
Kim Jae-Hoon
Kim Seon-Young
Kim Jeong-Hoon
Kim Jung-Ae
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Abstract
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Hepatocellular carcinoma (HCC) is an aggressive and incurable cancer. Although understanding of the molecular pathogenesis of HCC has greatly advanced, therapeutic options for the disease remain limited. In this study, we demonstrated that SETD5 expression is positively associated with poor prognosis of HCC and that SETD5 depletion decreased HCC cell proliferation and invasion while inducing cell death. Transcriptome analysis revealed that SETD5 loss downregulated the interferon-mediated inflammatory response in HCC cells. In addition, SETD5 depletion downregulated the expression of a critical glycolysis gene, PKM (pyruvate kinase M1/2), and decreased glycolysis activity in HCC cells. Finally, SETD5 knockdown inhibited tumor growth in xenograft mouse models. These results collectively suggest that SETD5 is involved in the tumorigenic features of HCC cells and that targeting SETD5 may suppress HCC progression.
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KEYWORD
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epigenetics, glycolysis, hepatocellular carcinoma, histone lysine methyltransferase, interferon response, SETD5
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