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KMID : 0578320220450100673
Molecules and Cells
2022 Volume.45 No. 10 p.673 ~ p.684
The Single-Cell Revelation of Thermogenic Adipose Tissue
Qi Yue

Hui Xiaoyan Hannah
Abstract
The past two decades have witnessed an upsurge in the appreciation of adipose tissue (AT) as an immuno-metabolic hub harbouring heterogeneous cell populations that collectively fine-tune systemic metabolic homeostasis. Technological advancements, especially single-cell transcriptomics, have offered an unprecedented opportunity for dissecting the sophisticated cellular networks and compositional dynamics underpinning AT remodelling. The "re-discovery" of functional brown adipose tissue dissipating heat energy in human adults has aroused tremendous interest in exploiting the mechanisms underpinning the engagement of AT thermogenesis for combating human obesity. In this review, we aim to summarise and evaluate the use of single-cell transcriptomics that contribute to a better appreciation of the cellular plasticity and intercellular crosstalk in thermogenic AT.
KEYWORD
adipose tissue, metabolism, obesity, single-cell sequencing, single-nucleus sequencing, thermogenesis.
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