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KMID : 0613820230330050406
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Journal of Life Science
2023 Volume.33 No. 5 p.406 ~ p.413
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Various Physiological and Anti-inflammatory Effects of Sanguisorba officinalis L. Roots as a Functional Cosmetic Material
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Park Seung-Mi
Oh Min-Jeong
Yeom Hyeon-Ji
Shim Mi-Ock
Lee Jin-Young
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Abstract
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In this study, the various physiological and anti-inflammatory activities of Sanguisorba officinalis L. roots (SR) were assessed for potential use as functional cosmetic materials. As a result of measuring electron-donating abilities to determine the antioxidant ability of SR extract, activity increased as the concentration increased, showing an excellent antioxidant capacity of 93.8% at a 1,000 μg/ml concentration. Further, the antioxidant power of SR extract, which was determined using an ABTS+ assay measurement, was more than 99% at concentrations of 50 μg/ml or more, while the tyrosinase inhibition rate was 37.7% at the highest concentration of 1,000 μg/ml. Consequently, the elastase and collagenase inhibition of SR extract measured 84.9% and 90.3%, respectively, at a 1,000-μg/ml concentration. As a result of confirming the survival rate of Raw 264.7 cells, the cell survival rate was determined to be 80% or more below a 100 μg/ml concentration, and subsequent cell-related experiments were conducted at concentrations below 100 μg/ml. Furthermore, after applying a NO assay to identify anti-inflammatory activity, it was confirmed that SR extract had an inhibitory rate of 50.8% at a concentration of 500 μg/ml, and it was excellent at suppressing the inflammatory expression. As a result of verifying protein expression by treating SR extract in Raw 264.7 cells, it was confirmed that expression was inhibited concentrated in all factors. Therefore, it is judged that SR can be used as a functional cosmetic material with antioxidant, whitening, and wrinkle-improving physiological effects and anti-inflammatory activities.
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KEYWORD
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Anti-inflammatory, COX-2, Cytokine, iNOS, Sanguisorba officinalis L. roots
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