|
KMID : 0616120210520030149
|
|
Korean Journal of Pharmacognosy
2021 Volume.52 No. 3 p.149 ~ p.156
|
|
|
Neuroprotective Activity of Spirulina maxima Hot Ethanol Extract
|
|
Ryu Ga-Hee
Ma Choong-Je
|
|
|
Abstract
|
|
|
|
Excessive glutamate can cause oxidative stress in neuronal cells and this can be the reason for neurodegenerative disease. In this study, we investigated the protective effect of Spirulina maxima hot ethanol extract on mouse hippocampal HT22 cell of which glutamate receptor has no function. HT22 cells were pre-treated with S. maxima sample at a dose dependent manner (1, 10 and 100 μg/ml). After an hour, glutamate was treated. Cell viability, reactive oxygen species (ROS) accumulation, Ca2+ influx, decrease of mitochondrial membrane potential level and glutathione related assays were followed by then. S. maxima ethanol extract improved the cell viability by suppressing the ROS and Ca2+ formation, retaining the mitochondrial membrane potential level and protecting the activity of the antioxidant enzymes compared with group of vehicle-treated controls. These suggest that S. maxima may decelerate the neurodegeneration by attenuating neuronal damage and oxidative stress.
|
|
|
KEYWORD
|
|
|
Spirulina maxima, Glutamate toxicity, HT22 cell, Neuroprotection, Neurodegeneration, Antioxidant
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|