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KMID : 0620719950010010001
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Natural Product Sciences
1995 Volume.1 No. 1 p.1 ~ p.4
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Isolation of Cytotoxic Compounds from the Leaves of Xantbium strumarium L .
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Ahn, Jong Woong
No, Zaesung/Ryu, Shi Yong/Zee, Ok Pyo/Kim, Seong Kie
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Abstract
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MeOH extract of the leaves of Xanthium strumarium L. were found to have cytotoxic activities against five human tumor cell lines. Cytotoxicity-guided chromatographic fractionation led to the isolation of the α-methylene containing sesquiterpenes, xanthatin, 8-epi-xanthatin and 8-epi-tomentosin. 8-epi-xanthatin was found to be far more cytotoxic than 8-epi-tomentosin, which lacks the conjugated enone moiety present in 8-epi-xanthatin.
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