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KMID : 0620719950010010055
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Natural Product Sciences
1995 Volume.1 No. 1 p.55 ~ p.60
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Isolation of Ethanol Metabolizing Enzyme Inhibitors from Aloe spp .
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Shin, Kuk Hyun
Woo, Won Sick/Chung, Ha Sook/Shim, Chang Sub
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Abstract
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In the course of evaluation of hepatoprotective components against alcohol-induced toxicity from Aloe spp., the methanol extract was found to cause a significant inhibition of rat liver cytosolic alcohol dehydrogenase activity. Systematic fractionation of active fractions monitored by bioassay led to isolation of four compounds; aloe-emodin, aloenin, ethylidene-aloenin and β-sitosterol, which were estimated as active principles for inhibition of c-ADH and c-ALDH activities in vitro.
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