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KMID : 0620719960020010024
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Natural Product Sciences
1996 Volume.2 No. 1 p.24 ~ p.28
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Antiinflammatory and Analgesic Effects of Higenamine, a Component of Aconiti Tuber
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Shin Kuk-Hyun
YunChoi Hye-Sook
Chung Ha-Sook
Koo Kyung-Ah
Kim Deuk-Joon
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Abstract
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The antiinflammatory and analgesic activities of higenamine were evaluated by measuring edema volume and pain threshold in adjuvant arthritic rats and acetic acid-induced writhing test in mice. Higenamine, with consecutive oral administrations at doses of 10 and 50 mg/kg/day, showed significant antiedemic effect and elevation of pain threshold during the secondary lesion of adjuvant arthritis. Higenamine also showed a significant inhibition of acetic acid-induced writhing syndrome with a single oral administration (200 mg/kg). From these results, it is postulated that higenamine might possess both of centrally and peripherally mediated analgesic properties.
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KEYWORD
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Higenamine, Aconiti Tuber, antiinflammatory action, analgesic action, adjuvant arthritis, acetic acid-induced writhing
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