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KMID : 0620719960020010048
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Natural Product Sciences
1996 Volume.2 No. 1 p.48 ~ p.55
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Inhibitory Effects of Triterpenoids on Interleukin-8/CINC-1 Induction in LPS-Stimulated Rat Peritoneal Macrophages
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Min Bok-Gi
Lee Gyeong-Im
Ha Joo-Young
Min Kyung-Rak
Kim Ju-Sun
Kang Sam-Sik
Kim Young-Soo
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Abstract
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The CINC-1 is a member of rat interleukin-8 with chemotactic and activating properties to neutrophils. The CINC-1 induction in LPS-stimulated rat peritoneal macrophages was analyzed using a sensitive enzyme-linked immunosorbent assay. The peritoneal macrophages contained about 3 ng/ml as a basal level, and induced to maximal 18 ng/ml of CINC-1 by stimulation with 5㎍/ml of LPS. Antiinflammatory steroids of dexamethasone and triamcinolon significantly suppressed the CINC-1 induction, where as aspirin and idomethacin did not show suppression. Inhibitory effects on the CINC-1 induction by natural triterpenoids having steroidal structures were analyzed. Among the 39 kinds of triterpenoids isolated from herbal medicines, acacigenin B and nigaichigoside F1 exhibited the highest suppression on the CINC-1 induction.
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KEYWORD
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Interleukin-8, CINC-1 induction, rat macrophages, triterpenoids
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