|
KMID : 0620719970030010038
|
|
Natural Product Sciences
1997 Volume.3 No. 1 p.38 ~ p.41
|
|
|
Hypoglycemic Activity of Ficus racemosa L. (Moraceae) Leaves in Streptozotocin-induced Diabetic Rats
|
|
Mandal Subhash C.
Mukherjee Pulok K.
Saha Kakali
Das J.
Pal M.
Saha B.P.
|
|
|
Abstract
|
|
|
|
The hypoglycemic effect of the extract of Ficus racemosa leaves was studied on streptozotocin-induced diabetic rats. Petroleum ether (60-80℃) extract of the plant obtained by soxhlet extraction from coarsely pulverised leaves was used. In the LD50 determination of the extract no abnormalities were observed at the dose range of 3 g/kg (p.o.) of the extract. The extract (200 mg/kg and 400 mg/kg orally) caused a reduction of blood glucose levels in streptozotocin-induced diabetic rats by 28.9% (P<0.00l) and 34.6% (P<0.001) respectively at the end of 9 days. The results. of this study indicate that the petroleum ether (60-80℃) extract of the leaves possesses significant hypoglycemic activity in hyperglycemic animals compared with glybenclamide as standard drug.
|
|
|
KEYWORD
|
|
|
Ficus racemosa, leaves, hypoglycemic activity, streptozotocin diabetic rats
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|