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KMID : 0620719980040030161
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Natural Product Sciences
1998 Volume.4 No. 3 p.161 ~ p.169
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Inhibitory Effect of Lichen Metabolites and their Synthetic Analogues on Melanin Biosynthesis in Cultured B-l6 Mouse Melanoma Cells
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Matubara, H .
Miharu, K ./Kinoshita, K ./Koyama, K ./Ye, Yang/Takahashi, K ./Yoshimura, I .
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Abstract
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The analogues of lichen components showing anti-tyrosinase activities were synthesized. 4-Alkylresorcinol derivatives showed both the inhibitory activity and cytotoxicity in B-16 melanona cells at the doses of 10 mM to 1.2 mM. Resorcinol and 4-methylresorcinol showed the inhibitory effect with a low cytotoxicity at the doses of 2.5 mM and 600 μM among 4-alkylresorcinols, respectively. Some diphenylmethane derivatives (Type A, B, and C) had strong activities with a low cytotoxicity. While xanthene derivatives had no effect. Glucosides of 4,5-alkylresorcinol and the diphenylmethaney derivative (Type B) were prepared to decrease the cytotoxicity. As result, no effect were observed. Liposome of the diphenylmethane derivative (Type B) was prepared for the same purpose, and the later showed a remarkable effect at the dose at 1.5 μM with a low cytotoxicity.
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