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KMID : 0620719990050020070
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Natural Product Sciences
1999 Volume.5 No. 2 p.70 ~ p.74
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Inhibitory Principles from Magnolia officinalis on Tumor Necrosis Factor-α Production in Lipopolysaccharide - Activated RAW264.7 cells
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Park, Myung Hwan
Baik, Kyong Up/Yoo, Eun Sook/Cho, Jae Youl/Park, Jisoo/Chae, Sook Hee/Lee, June Goo
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Abstract
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In the course of a search for tumor necrosis factor (TNF)-α inhibitory compounds from medicinal plants, we identified neolignans, honokiol and magnolol, from the alcoholic extract of Magnolia officinalis as active inhibitory principles. These compounds dose-dependently inhibited TNF-α production without displaying cytotoxicity and their inhibitory activities measured by IC_(50) values were 53.7 and 61.4 μM, respectively.
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