|
KMID : 0620720000060010016
|
|
Natural Product Sciences
2000 Volume.6 No. 1 p.16 ~ p.19
|
|
|
Monoamine Oxidase Inhibitors from Cinnamomi Cortex
|
|
Huong Dang Thi Lan
Jo Young-Su
Lee Myung-Koo
Bae Ki-Hwan
Kim Young-Ho
|
|
|
Abstract
|
|
|
|
Four compounds were isolated from the dichloromethane fraction of Cinnamomi Cortex through bioassay-guided isolation. Their structures were identified as coumarin (1), 3,3-dimethoxy-1-propenyl benzene (2), cinnamic acid (3) and o-methoxy cinnamaldehyde (4) on the basis of spectroscopic data. All four compounds showed inhibitory activities in vitro against monoamine oxidase (MAO) prepared by mouse brain. The IC50 values were 41.4 μM (1), 110.6 μM (2), 252.5μM (3) and 83.1 μM (4), respectively.
|
|
|
KEYWORD
|
|
|
Cinnamomi Cortex, Lauraceae, monoamine oxidase inhibition, coumarin, 3, 3-dimethoxy-1-propenyl benzene, cinnamic acid, o-methoxy cinnamaldehyde
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|