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KMID : 0620720000060020070
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Natural Product Sciences
2000 Volume.6 No. 2 p.70 ~ p.72
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Inhibitory Effects of Coptisine on Monoamine Oxidase Activity
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Hong, Seung Soo
Kim, Hack Seang/Lee, Myung Koo/Ro, Jai Seup/Lee, Kyong Soon
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Abstract
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The effects of coptisine on monoamine oxidase (EC 1.4.3.4; MAO) activity in mouse brain were investigated. Coptisine showed an inhibitory effect on MAO activity with a concentration-dependent manner. Coptisine exhibited 51.0% inhibition of MAO activity at 9 μM. The IC_(50) value of coptisine was 8.7 μM. Coptisine inhibited MAO activity competitively with kynuramine as a substrate. The K_i value of coptisine was 4.1 μM. These results indicate that coptisine functions to regulate the catecholamine content at biologically active sites.
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