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KMID : 0620720000060040155
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Natural Product Sciences
2000 Volume.6 No. 4 p.155 ~ p.160
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Palm Vitamin E Prevents Osteoporosis in Orchidectomized Growing Male Rats
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Khalid, B . A . K .
Nirwana, S . Ima/Kiftiah, A ./Zainal, A . G ./Norazlina, M ./Gapor, M . T .
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Abstract
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Testosterone deficiency increased bone resorption, giving rise to osteoporosis. Testosterone deficiency also increased lipid peroxidation and free radical formation. Free radicals have been shown to be toxic to osteoblasts as well as to activate osteoclasts. In this study, the effects of giving an antioxidant, i.e. vitamin E-rich extract from palm oil on bone mineral density and calcium content was studied. Palm vitamin E prevented the loss in bone mineral density due to orchidectomy, seen in the whole femur, proximal amd midshaft regions, as well as L4 vertebra. Similar observations were seen in bone calcium content of the L5 vertebra. Giving palm olein also prevented the loss in bone mineral density in the femoral midshaft and L4 vertebra; and bone calcium content in the L5 vertebra. In conclusion, vitamin E-rich extract from palm oil was effective in preventing the toss in bone mineral density and calcium content of orchidectomized male rats. This action is probably due to its role as an antioxidant.
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