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KMID : 0620720000060040161
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Natural Product Sciences
2000 Volume.6 No. 4 p.161 ~ p.164
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The Purgative Action of Rhei Rhizoma Is Increased by Raphani Semen
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Kim, Dong Hyun
Kim, Young Suk/Park, EUN KYUNG/Lee, Kyung Sup/Bae, Hyung Sup/Kim, Jung Jin/Joh, Ki Ho
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Abstract
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Herbal medicinal interaction on the purgative action of Chungpesagan-tang, which is one of the traditional Korean medical prescriptions that has been most frequently used for stroke was investigated. Chungpesagan-tang had more potent purgative activity than Rhei Rhizome alone. When each Chungpesagan-tang composing herbal medicine with Rhei Rhizome was extracted with water, water extract of Raphani Semen with Rhei Rhizome had the most potent purgative activity. However, Raphani Semen had not purgative activity. When Rhei Rhizome with Raphani Semen was extracted, sennoside A content in the water extract was increased. The transformation of sennoside A of Rhei Rhizome to rheinanthrone by human intestinal microflora was weakly induced by Raphani Semen. These results suggest that the purgative action of Chungpesagan-tang could be controlled by the addition and subtraction of Chungpesagan-tang-composing herbal medicines.
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