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KMID : 0620720010070030063
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Natural Product Sciences
2001 Volume.7 No. 3 p.63 ~ p.67
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Hepatoprotective Activity of Chungpesagan - tang is Related to the Inhibition of β - Glucuronidase
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Kim, Dong Hyun
Kim, Young Suk/Lee, Kyung Sup/Kim, Jae Kwan/Cho, Ki Ho/Bae, Hyung Sup/Lee, Hae Ung
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Abstract
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β-Glucuronidase-inhibitory and hepatoprotective effects of Chungpesagan-tang, which has been used for liver diseases and stroke, on CCl₄-induced hepatotoxicity of rats was investigated. Chungpesagan-tang potently inhibited β-glucuronidases. Serum AST, ALT and LDH levels of the CCl₄ group orally treated with Chungpesagan-tang (100 ㎎/㎏) were lowered to 47, 28 and 58% of the CCl₄-treated group, respectively. Among the ingredients of Chungpesagan-tang, Puerariae Radix, Scutellariae Radix and Rhei Rhizoma potently inhibited the β-glucuronidases and protected CCl₄-induced liver injury. The hepatoprotective activity of Puerariae Radix was affected by ingredients of Chungpesagan-tang: Scutellariae Radix had the synergistic activity, but Angelicae Tenussimae Radix exhibited the antagonistic activity. These results suggest that the β-glucuronidase inhibitor of herbal medicines may protect CCl₄-induced liver injury and puerarin should be a natural prodrug for the hepatoprotective effect.
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