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KMID : 0620720010070040095
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Natural Product Sciences
2001 Volume.7 No. 4 p.95 ~ p.101
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Effect of Terminalia chebula on Immediate Hypersensitivity Reaction in Mice and Rats
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Kim, Sang Yong
Lee, Jae Kwan/Shin, Tae Yong
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Abstract
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We investigated the effect of aqueous extract of Terminalia chebula (Combretaceae) (TCAE) on the immediate hypersensitivity reaction in viva and in vitro. TCAE (0.01 to 1 g/㎏) dose-dependently inhibited compound 48/80 induced systemic anaphylaxis in mice. When TCAE was pretreated at concentrations ranging from 0.01 to 1 g/㎏, the plasma histamine levels were reduced in a dose-dependent manner. TCAE (0.1 and 1 g/㎏) significantly inhibited local immunoglobulin E (IgE)-mediated passive cutaneous anaphylactic reaction. TCAE (0.001 to 1 ㎎/㎖) also dose-dependently inhibited the histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or antidinitrophenyl (DNP) IgE. TCAE (0.01 to 1 ㎎/㎖) had a significant inhibitory effect on anti-DNP IgE-induced tumor necrosis factor-α production from RPMC. These results indicate that TCAE inhibits immediate hypersensitivity reaction in vivo and in vitro.
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