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KMID : 0620720020080030097
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Natural Product Sciences
2002 Volume.8 No. 3 p.97 ~ p.99
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Analgesic, Anti-inflammatory and Diuretic Activities of Pisonia grandis
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Anbalagan, N.
Rajinikanth, K. N./Gnanasam, S. Kishore/Leonard, J. Thomas/Balakrishna, K./Ramachandran, S./Sridhar, S. K.
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Abstract
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In the present study, Pisonia grandis leaves were extracted with chloroform and methanol. The extracts were vacuum dried to yield the respective chloroform (CE) and methanol extract (ME). CE and ME were evaluated for analgesic, anti-inflammatory (acute and chronic) and diuretic activity at 2 dose levels (250 and 500㎎/㎏). Significant analgesic and anti-inflammatory activities were associated with CE and ME. CE at the dose level of 500㎎/㎏ was found to exhibit equivalent chronic anti-inflammatory activity as diclofenac at 50㎎/㎏ dose level. Significant diuretic activity was exhibited by ME. Graded dose response for all the activities were observed for the extracts.
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