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KMID : 0620720020080040133
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Natural Product Sciences
2002 Volume.8 No. 4 p.133 ~ p.136
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Composition of the Essential Oil of Chrysanthemum sibiricum, and Cytotoxic Properties
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Lee, Kyung-Tae
Choi, Jongwon/Park, Jong-Hee/Jung, Won-Tae/Jung, Hyun-Ju/Park, Hee-Juhn
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Abstract
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GC-MS data on the volatile oil(CS-oil) of Chrysanthemum sibiricum herbs led to the identification of 2-methoxythianisol, (＋)-camphor, geraniol, citral, thymol, eugenol, β-caryophyllene oxide, β-caryophyllene, β--eudesmol, juniper camphor together with an unknown substance using the mass spectral library and literature data. CS-oil exhibited significant cytotoxicities on HL-60 (IC_50 12.5㎍/ml) cell and mild on HepG-2 cell(IC_50 102.4㎍/ml), though the antioxidant ability was found not to be potent (IC_50 97.2㎍/ml). However, the component eugenol showed potent antioxidant ability the mild cytotoxicity. Methy leugenol with no phenolic OH showed less potent cytotoxic and antioxidative properties than eugenol suggesting that phenolic OH plays an important role for the cytotoxic and antioxidant abilities. The oil-pretreatment prevented lipid peroxidation induced by bromobenzene in the rat. Therefore, it was demonstrated that CS-oil could be a cytotoxic agent with antioxidant properties.
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