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KMID : 0620720020080040147
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Natural Product Sciences
2002 Volume.8 No. 4 p.147 ~ p.151
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Anti-platelet Effect of the Phenolic Constituents Isolated from the Leaves of Magnolia obovata
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Pyo, Mi Kyung
Koo, Yean Kyoung/Yun-Choi, Hye Sook
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Abstract
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In the course of our work on anti-platelet constituents from plants, eight phenolic compounds, (±)-syringaresinol (1), 4-hydroxybenzaldehyde (2), 4-hydroxybenzoic acid (3), vanillic acid (4), 4-hydroxy cinnamic acid (5), quercetin 3-O-rhamnoside (6), rutin (7), and quercetin 3-(2^G-rhamnosylrutinoside) (8) were isolated from the methanol extract of the leaves of Magnolia obovata. The compounds were identified based on the spectroscopic data. Compound 2, 3, 5, 6, 7 and 8 were isolated for the first time from genus Magnolia. 1 and 6 showed same order of inhibitory potencies as acetylsalicylic acid (ASA) to rat platelet aggregation induced by all the stimulators tested. The remaining six compounds showed only mild effects.
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