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KMID : 0620720020080040162
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Natural Product Sciences
2002 Volume.8 No. 4 p.162 ~ p.164
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Evaluation of DNA Strand-Scission Activity of the Korean Indigenous Plants
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Choi, Hye-Young
Han, Ah-Reum/Mar, Woongchon/Seo, Eun-Kyoung
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Abstract
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The methanol extracts of 42 Korean indigenous plants were evaluated for the DNA strand-scission activity. As a result, the 17 extracts were found to be active in the criteria of IC_50＜25㎍/ml. Among others, the MeOH extracts of Caesalpinia sappan and Mucuna birdwoodiana showed the most potent DNA strand-scission activity with IC_50 values of 5.9 and 4.9㎍/ml, respectively. Therefore, the partition and fractionation for C. sappan were performed and tested in the DNA strand-scission assay system for further bioassay-guided fractionation.
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