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KMID : 0620720020080040170
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Natural Product Sciences
2002 Volume.8 No. 4 p.170 ~ p.172
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Cytotoxic Activities of Indigenous Plant Extracts in Cultured Human Cancer Cells
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Min, Hye-Young
Park, Hyen-Joo/Kim, Youngleem/Lee, Eun-Jin/Hwang, Hye-Jin/Park, Eun-Jung/Lee, Sang Kook
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Abstract
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In continuous efforts for discovery of novel potent antitumor agents from natural products, fifty-seven methanolic extracts derived from indigenous Korean plants were primarily evaluated for in vitro cytotoxic activity in cultured human lung (A549) and colon (Co12) cancer cells. As a result, 16 plant extracts were found to be active against A549 cells and 15 extracts were active against Co12 cells in the criteria of IC_50＜50㎍/ml. In particular, the extracts of Calystegia soldanella (IC_50 = 8.0㎍/ml in A549;IC_50 = 27.4㎍/ml in Co12), Heloniopsis orientalis (IC_50 = 4.6㎍/ml in A549;IC_50 = 4.5㎍/ml in Co12), and Thuja koraiensis(IC_50 = 1.2㎍/ml in A549;IC_50 = 0.6㎍/ml in Co12) showed a potent cytotoxic activity. Further study for the identification of active compounds from these lead extracts might be warranted.
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