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KMID : 0620720020080040177
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Natural Product Sciences
2002 Volume.8 No. 4 p.177 ~ p.182
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Sanguisorba officinalis Inhibits Immediate-type Allergic Reactions
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Kim, Sung-Hwa
Kim, Dae-Keun/Eom, Dong-Ok/Kim, Sang-Yong/Kim, Sang-Hyun/Shin, Tae-Yong
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Abstract
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The effect of aqueous extract of Sanguisorba officinalis L. (Rosaceae) root (SOAE) on the immediatetype allergic reactions by anal therapy was investigated. SOAE (0.01 to 1 g/㎏) dose-dependently inhibited systemic anaphylaxis induced by compound 48/80 in mice. When SOAE was pretreated at the same concentrations with systemic anaphylaxis, the plasma histamine levels were reduced in a dose-dependent manner. SOAE (0.1 and 1 g/㎏) also significantly inhibited local anaphylaxis activated by anti-DNP IgE. SOAE (0.001 to 1 ㎎/ml) dose-dependently inhibited the histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. The level of cyclic AMP (cAMP) in RPMC, when SOAE (1 ㎎/ml) was added, transiently and significantly increased compared with that of basal cells. These results provide evidence that anal therapy of SOAE may be beneficial in the treatment of allergic diseases.
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KEYWORD
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