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KMID : 0620720030090020083
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Natural Product Sciences
2003 Volume.9 No. 2 p.83 ~ p.86
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Hepatoprotective Activity of Thespesia populnea Bark Extracts against Carbon Tetrachloride-Induced Liver Toxicity in Rats
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Ilavarasan, R.
Vasudevan, M./Anbazhagan, S./Venkataraman, S./Sridhar, S. K.
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Abstract
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In the present study, Thespesia populnea (Malvaceae) bark was extracted with methanol and water. The extracts were vacuum dried to yield the respective methanol(MET) and aqueous extract (AET). The extracts were evaluated for hepatoprotective activity against carbon tetrachloride (CCI_4) induced liver damage at 2 dose level (250 and 500㎎/㎏). The biochemical parameters observed in serum were total bilirubin, alkaline phosphatase (ALP), serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) levels and total protein. Aspartate transaminase (AST), alanine transaminase (ALT) and total protein levels in liver were also evaluated. Histopathological study on the liver tissue was also performed. The extracts exhibited dose dependent reduction in total bilirubin, ALP, SGOT, SGPT, AST, ALT and increase in total protein (serum and liver) levels. The extracts also exhibited only mild hepatocytic damage compared to the CCI_4 treated group. MET was found to exhibit higher hepatoprotection than AET.
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