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KMID : 0620720030090020105
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Natural Product Sciences
2003 Volume.9 No. 2 p.105 ~ p.108
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DNA Strand-Nicking Principles of Mucuna birdwoodiana
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Han, Ah-Reum
Mar, WoongChon/Seo, Eun-Kyoung
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Abstract
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During our research program to find DNA strand-scission agents from higher plants, the MeOH extracts of the stems of Mucuna birdwoodiana Tutcher. (Leguminosae) exhibited the most potent activity with an IC_50 value of 4.9㎍/ml. Thus, detailed laboratory investigation was performed, and led to the isolation of known compounds, (±)-catechin (1) and (-)-epicatechin (2) as active principles. Compounds 1 and 2 showed significant activity of DNA strand-scission with IC_50 values of 10.8 and 7.5㎍/ml, respectively (positive control, bleomycin: IC_50 3.3㎍/ml).
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KEYWORD
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