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KMID : 0620720030090020112
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Natural Product Sciences
2003 Volume.9 No. 2 p.112 ~ p.116
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Antitumor and Immunostimulating Activities of Acanthopanax sessiliflorus Fruits
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Lee, SangHyun
Lee, Yeon Sil/Jung, Sang Hoon/Ji, Jun/Shin, Kuk Hyun/Kim, Bak-Kwang/Kang, Sam Sik
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Abstract
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The antitumor and immunostimulating activities of Acanthopanax sessiliflorus fruits were investigated. Polysaccharide isolated from this plant, when administered consecutively for 9 dyas at 50 and 100㎎/㎏ i.p. in mice, caused a significant increase in the life span and a significant decrease in the tumor weight and volume in mice inoculated with Sarcoma-180 tumor cells. Polysaccharide was also demonstrated to exhibit phagocytosis-enhancing activity as measured by the carbon clearance in mice. Polysaccharide, when administered i.p. at 50 and 100㎎/㎏/day for 3 consecutive days, exhibited a significant RCtr/RCc [the rate of regression coefficient of the animals treated (RCtr) to that of the control (RCc)], being 1.44 (PI = 1), 1.52 (PI = 2) which was approximately the same with that of enhancement of phagocytosis, its potency as expressed by the regression coefficient ratio of zymosan (RCtr/RCc = 1.55, PI = 2), a typical phagocytosis enhancer. Polysaccharide also caused a significant increase in the acid phosphatase activity representing lysosomal enzymes in macrophages at 1-100 ig/ml in vitro in compliance with in vivo results. These results suggest that the antitumor activity of polysaccharide might be related to be immunostimulating function.
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KEYWORD
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