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KMID : 0620720030090030158
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Natural Product Sciences
2003 Volume.9 No. 3 p.158 ~ p.160
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Inhibitory Effect of Ginseng Polyacetylenes on Infection and Vacuolation of Helicobacter pylori
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Kim, Jong-Mi
Shin, Ji-Eun/Han, Myung Joo/Baek, Nam-In/Kim, Dong-Hyun
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Abstract
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Polyacetylenes were isolated from Panax C.A. Meyer (Family Araliaceae), and their inhibitory effects on growth, infection and VacA vacuolation of Helicobacter pylori (HP) were investigated. Ginsseng polyacetylenes did not inhibit the infection of HP into KATO cells. However, polyacetylenes inhibited HP growth and vacuolation of HeLa by VacA toxin. Panaxytriol showed the most potent inhibition with IC_(50) values of 0.05 and 0.046 mg/ml, respectively.
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