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KMID : 0620720030090030170
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Natural Product Sciences
2003 Volume.9 No. 3 p.170 ~ p.173
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Antioxidant Activities of Decursinol Angelate and Decursin from Angelica gigas Roots
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Lee, Sanghyun
Lee, Yeon Sil/Jung, Sang Hoon/Shin, Kuk Hyun/Kim, Bak-Kwang/Kang, Sam Sik
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Abstract
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The anti-oxidant activities of decursinol angelate (1) and decursin (2) isolated from Angelica gigas were investigated. These two coumarins exhibited decrease in serum transaminase activities elevated by hepatic damage induced by CCI_(4)-intoxication in rats. They also showed increase in anti-oxidant enzymes such as hepatic cytosolic superoxide dismutase (SOD), catalase, and glutathione peroxidase (GSH-px) in CCI_(4)intoxicated rats. These rssults suggest that decursinol angelate(1) and decursin(2) from A. gigas possess not onlt the anti-oxidant, but also the hepatoprotective activities in rats.
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