|
KMID : 0620720030090040278
|
|
Natural Product Sciences
2003 Volume.9 No. 4 p.278 ~ p.285
|
|
|
Inhibition of Porcine Pancreatic Elastase (PPE) by Korean Mistletoe (Viscum album var. coloratum) Fractions
|
|
Lyu, Su Yun
Moon, You Sun/Kwon, Young Ju/Joo, Hye Jin/Park, Won Bong
|
|
|
Abstract
|
|
|
|
The serine proteases such as human leukocyte elastase (HLE) and porcine pancreatic elastase (PPE) are classified in the chymotrypsin family, and possibly the most destructive enzymes having the ability to degrade virtually all of the connective components in the body, In the present study, the extracts of water and methanol of Korean mistletoe (Viscum album var. coloratum) inhibites significantly the PPE activity. The fractions eluated on Amberlite XAD-2 from methanol extract were furgher purified on the repeated SiO_(2) column chromatography and the fractions A, B and C were eluated. The fractions A, B and C at 3 mg/ml inhibited significantly the PPE activity up to 66%, 95% and 85%, respectively. In conclusion, the fraction Aassumed as lignans or phenylpropanes, and fraction B to C assumed as triterpenoids showed the PPE inhibitory effects on the PPE and that these compounds in mistletoe may be used for treatment of pathological processes such as age-dependent tissue loss or inflammation.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|