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KMID : 0620720040100010001
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Natural Product Sciences
2004 Volume.10 No. 1 p.1 ~ p.10
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Anti-inflammatory Flavonoids: Modulators of Proinflammatory Gene Expression
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Kim Hyun-Pyo
Son Kun-Ho
Chang Hyun-Wook
Kang Sam-Sik
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Abstract
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Plant flavonoids possess anti-inflammatory activity in vitro and in vivo. Although the action mechanisms are not fully understood, recent studies have clearly shown that certain flavonoids, especially flavone derivatives, express their anti-inflammatory activity at least in part by modulation of proinflammatory gene expression such as cyclooxygenase-2, inducible nitric oxide synthase and various cytokines. This review summarizes the recent findings of flavonoids modulating expression of proinflammatory molecules.
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KEYWORD
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Flavonoid, inflammation, gene expression, phospholipase, cyclooxygenase, nitric oxide synthase, interleukin
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