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KMID : 0620720040100020080
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Natural Product Sciences
2004 Volume.10 No. 2 p.80 ~ p.84
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Rosmarinic Acid as a Tyrosinase Inhibitors from Salvia miltiorrhiza
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Kang, Hye Sook
Kim, Hyung Rak/Byun, Dae Seok/Park, Hye Jin/Choi, Jae Sue
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Abstract
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Rosmarinic acid and its methy1 ester, isolated from the ehty1 acetate soluble fraction of the methanolic extract of Salvia miltiorrhiza Bunge (Labiatae), were found to inhibit the oxidation of L-tyrosine catalyzed by mushroom tyrosinase with the IC_(50) values of 16.8 and 21.5 μM, respectively. It was comparable with kojic acid, a well-known tyrosinase inhibitor, with an IC_(50) of 22.4 μM, The inhibitory kinetics analyzed by the Lineweaver-Burk plots, were found rosmarinic acid and its methy1 ester to be competitive inhibitors with K_(i) OF 2.4 ×10^(-5) and 1.5×10^(-5)M, respectively.
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KEYWORD
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