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KMID : 0620720040100020085
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Natural Product Sciences
2004 Volume.10 No. 2 p.85 ~ p.88
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Evaluation on the P-Glycoprotein Inhibitory Activity of Indonesian Medicinal Plants
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Go, Eun Jung
Kim, Hyang Rim/Chung, Soo Yeon/Jeong, Yeon-Hee/Kim, Na Hyung/Han, Ah-Reum/Seo, Eun-Kyoung
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Abstract
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One hundred Indonesian plant extracts were screened to investigate their effects on the P-glycoprotein (P-gp) activity in human uterine sarcoma cells, MES-SA/DX5, for the first time. Among others, four samples, Alpinia galanga (BuOH ext.), Sindora sumatrana (CHCI_(3) ext.) Strychnos ligustrina (CHCI_(3) ext.), and Zingiber cassumunar Roxb (hexane ext.), exhibited the most potent inhibition on the P-gp activity. They increased cytotoxic activity of daunomycin up to IC_(50) values of less than 1.41 μM, which is a value with a positive control, verapamil. Other 25 samples showed significant P-gp inhibitory activity with IC_(50) values between 1.4 and 4.0 μM, These prospective samples will be subjected to fruther laboratory phytochemical investigation to find active principles.
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KEYWORD
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