|
KMID : 0620720040100030104
|
|
Natural Product Sciences
2004 Volume.10 No. 3 p.104 ~ p.108
|
|
|
Lignans from the Fruits of Schizandra chinensis and Their Inhibitory Effects on Dopamine Content in PC12 Cells
|
|
Seo Seon-Mi
Lee Hak-Ju
Park Young-Ki
Lee Myung-Koo
Park Jae-In
Paik Ki-Hyon
|
|
|
Abstract
|
|
|
|
Five lignans including gomisin N (1), wuweizisu C (2), gomisin L1 (3), (+)-deoxyschizandrin (4), and gomisin J (5) have been isolated from the fruits of Schizandra chinensis. The structures of the isolated compounds were elucidated by analyzing MS and NMR spectra. Effects of the compounds isolated in this study on the dopamine content in PC12 cells were investigated to evaluate their inhibitory effectiveness. The gomisin N, wuweizisu C, and gomisin J showed 25.4%, 39.8%, and 35.1 %, respectively, inhibition effect on dopamine content in PC12 cells at the concentration of 50㎍/ml .
|
|
|
KEYWORD
|
|
|
Schizandra chinensis, Schizandraceae, lignans, dopamine content
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|