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KMID : 0620720040100050197
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Natural Product Sciences
2004 Volume.10 No. 5 p.197 ~ p.206
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Molecular Mechanisms of Regulation of Human Cytochrome P4501A2 Gene Expression
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Chung In-Jae
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Abstract
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Cytochrome P4501A2 (CYP1A2) is responsible for the metabolic activation of a number of aromatic amines and amides to mutagenic and carcinogenic moieties. Considerable variations in the level of CYP1A2 expression in humans have been reported. Thus, the level of human CYP1A2 may determine an individuals susceptibility to these chemicals. Given its importance, the molecular mechanisms of CYP1A2 regulation have been studied by many groups. Direct interactions between transcription factors with the promoters of the gene represent one of the primary means by which the expression of CYP1A2 is controlled. In this review, several important cis elements, transcription factors and the effects of deacetylation/methylation of promoter regions that play an important role in the induction by PAHs as well as constitutive expression of human CYP1A2 are discussed.
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KEYWORD
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Cytochrome P4501A2, CYP1A2, gene expression, promoter, transcription facror
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