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KMID : 0620720040100060268
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Natural Product Sciences
2004 Volume.10 No. 6 p.268 ~ p.271
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P-Glycoprotein Inhibitory Activity of Indonesian Medicinal Plants in Human Breast Cancer Cells
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Kim Hyang-Rim
Chung Soo-Yeon
Jeong Yeon-Hee
Go Eun-Jung
Han Ah-Reum
Kim Na-Hyung
Sung Min-Kyung
Song Gi-Na
Jang Jung-Ok
Nam Joo-Won
Lee Hwa-Jeong
Seo Eun-Kyoung
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Abstract
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In order to examine their effects on the P-glycoprotein (P-gp) activity in human breast cancer cells, MCF-7/ADR, one hundred Indonesian plant extracts were screened. Among them, the five chloroform extracts of Calotropis gigantea, Curcuma aeruginosa, Merremia mammosa, Sindora sumatrana, and Zingiber cassumunar, showed the most potent P-gp inhibitory activity. When each of these extracts was treated together with the anticancer agent, daunomycin, they increased the cytotoxic activity of daunomycin up to IC50 values of less than 6.62 μM, which is a value with a positive control, verapamil. Also, other 15 plant extracts exhibited significant P-gp inhibitory activity with IC50 values between 6.62 and 13.20 μM. These prospective samples will be subjected to further laboratory phytochemical investigation to find active principles.
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KEYWORD
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P-glycoprotem, Indonesian plants, MCF-7/ADR cell, daunomycin
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