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KMID : 0620720040100060344
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Natural Product Sciences
2004 Volume.10 No. 6 p.344 ~ p.346
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Nitric oxide and ProstaglandinE₂Synthesis Inhibitory Activities of Flavonoids from the Barks of Ulmus macrocarpa
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Kim Hyun-Jung
Yeom Seung-Hwan
Kim Min-Kee
Shim Jae-Gul
Lim Hyun-Woo
Lee Min-Won
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Abstract
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Eight phenolic compounds (1-8) which were isolated from the barks of Ulmus macrocarpa were evaluated for their inhibitory activities on nitric oxide (NO) and prostagrandin E₂(COX-2) production in interferon-γ (INF-γ) and lipopolysaccharide (LPS)-activated RAW 264.7 cells in vitro. NO and COX-2 levels were moderately reduced by the addition of compounds (1-8). Among them 3,4,5,6,7 and 8 inhibited NO production in a dose dependent manner with an IC50 of 92.2, 97.3, 36.1, 43.5, 32.8, 39.4 and 37.1 ㎍/ml, respectively (positive control, L-NMMA; 36.4 ㎍/ml), and 3,4,5,6,7 and 8 reduced the COX-2 level in a dose dependent manner with an IC50 of 43.2, 24.8, 24.8, 33.4, 44.8 and 22.7 ㎍/ml, respectively (positive control, indomethacin; 23.4 ㎍/ml). These results suggest that the phenolic compounds may be developed as potential anti-inflammatory and cancer chemopreventive agents.
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KEYWORD
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Ulmus marcroparca, Ulmaceae, flavanone, flavan 3-ol, Nitric oxide, cyclooxygenase-2, anti-inflammation, cancer chemoprevention
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