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KMID : 0620720040100060347
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Natural Product Sciences
2004 Volume.10 No. 6 p.347 ~ p.352
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Biotransformation of Ginseng Extract to Cytotoxic Compound K and Ginsenoside Rh₂by Human Intestinal Bacteria
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Bae Eun-Ah
Choo Min-Kyung
Lee Young-Chul
Kim Dong-Hyun
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Abstract
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When saponin extracts of dried ginseng and red ginseng were anaerobically incubated with human intestinal microflora, these extracts were metabolized to compound K and ginsenoside Rh₂, respectively. However, when these extracts were incubated with commercial lactic acid bacteria, these did not metabolize these ginsenosides to compound K or ginsenoside Rh₂. Among some intestinal bacteria isolated from human feces, Bacteroides C-35 and C-36 transformed these saponin extracts to compound K and ginsenoside Rh₂, respectively. These bacteria also transformed water extracts of dried ginseng and red ginseng to compound K and ginsenoside Rh₂, respectively, similarly with that of the saponin extracts. Among transformed ginsenosides, compound K and 20(S)-ginsenoside Rh₂exhibited the most potent cyotoxicity against tumor cells.
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KEYWORD
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ginseng, intestinal bacteria, transformation, compound K, ginsenoside Rh₂, cytotoxicity
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