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KMID : 0620720050110020089
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Natural Product Sciences
2005 Volume.11 No. 2 p.89 ~ p.91
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Honokiol : A Noncompetitive Tyrosinase Inhibitor from Magnoliae Cortex
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Tian Yu-Hua
Kang Tai-Hyun
Kim Hyun-Chul
Kim Youn-Chul
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Abstract
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Effect of the neolignans, honokiol (1) and magnolol (2), isolated from Magnoliae Cortex on mushroom tyrosinase activity was investigated in vitro using L-tyrosine as a substrate. Honokiol (1) inhibited tyrosinase activity significantly in a concentration-dependent manner, on the other hand, magnolol (2) did not show tyrosinase inhibitory effect. Honokiol exhibited tyrosinase inhibitory effect with IC50 value of 67.9 μM, and proved to act as a non-competitive inhibitor by the analysis of Lineweaver-Burk plot.
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KEYWORD
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Honokiol, Tyrosinase inhibitor, Magnoliae Cortex
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