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KMID : 0620720050110030127
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Natural Product Sciences
2005 Volume.11 No. 3 p.127 ~ p.130
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Inhibitory Effects of Paeonia suffruticosa Extracts on Maltase and Sucrase
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Lee Sung-Jin
Ji Seung-Tack
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Abstract
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This study was carried out to investigate inhibitory effect of extracts from root cortex of Paeonia suffruticosa on α-glucosidose EC 3. 2. 1. 20) and postprandial hyperglycemia. Methanol extract and organic solvent (n-hexane, ethyl acetate, butanol, aqueous) fractions from the crude drug were determined for the inhibitory activities against maltase, sucrase and α-glucosidose. The methanol extract from the crude drug strongly inhibited maltase (72%) and sucrase (76%) at the concentration of 100 ㎛/ml Among the fractions examined, the ethyl acetate fraction from the natural plant drug showed potent inhibitory effects on maltase (85%) and sucrase (81%) at the concentration of 100 ㎛/ml. The ethyl acetate fraction from root cortex of Paeonia suffruticosa also exhibited significant reductions (21%) of blood glucose elevation in mice loaded with maltose.
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KEYWORD
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Paeonia suffruticosa, postprandial hyperglycemia, α-glucosidose
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