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KMID : 0620720050110030136
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Natural Product Sciences
2005 Volume.11 No. 3 p.136 ~ p.138
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Antibacterial and Radical Scavenging Epoxycyclohexenones and Aromatic Polyols from a Marine Isolate of the Fungus Aspergillus
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Li Yong
Li Xifeng
Son Byeng-Wha
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Abstract
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Bioassay-guided fractionation of an organic extract of the broth from the marine-derived fungus of the genus Aspergillus led to the isolation of the polyketides, (+)-epoxydon (1), (+)-epoxydon monoacetate (2), gentisyl alcohol (3), 3-chlorogentisyl alcohol (4), and methylhydroquinone (5). Compounds 1-5 showed a potent antibacterial activity against the methicillin-resistant and multidrug-resistant Staphylococcus aureus (MRSA and MDRSA) with MIC (minimum inhibitory concentration) values of 12.5, 12.5, 12.5, 50.0, and 6.2 ㎍/mL, respectively. Compounds 1-4 also exhibited a significant radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) with IC50 values of 6.0, 15.0, 7.0, and 1.0 μM, respectively.
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KEYWORD
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Aspergillus, (+)-epoxydon, (+)-epoxydon monoacetate, gentisyl alcohol, 3-chlorogentisyl alcohol, methylhydroquinone, antibacterial activity, radical scavenging activity
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