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KMID : 0620720050110030145
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Natural Product Sciences
2005 Volume.11 No. 3 p.145 ~ p.149
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Monoamine Oxidase Inhibitor from Uncaria rhynchophylla
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Hong Seong-Soo
Han Xiang Hua
Park So-Young
Choi Woo-Hoi
Lee Myung-Koo
Hur Jae-Doo
Hwang Bang-Yeon
Ro Jai-Seup
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Abstract
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A methanol soluble extract from the dried hooks and stems of Uncaria rhynchophylla showed a strong inhibitory activity against monoamine oxidase in mouse brain. Using a bioassay-guided purification of this extract, a known β-carboline type alkaloid, harman (1), was obtained as an active constituent. In addition, five known indole alkaloids, isocorynoxeine (2), isorhynchophylline (3), corynoxeine (4), cadambine (5), and 3α-dihydrocadambine (6), were isolated and found to be weakly active or inactive.
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KEYWORD
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Uncaria rhynchophylla, Rubiaceae, Harman, Monoamine oxidase inhibitor
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