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KMID : 0620720050110030150
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Natural Product Sciences
2005 Volume.11 No. 3 p.150 ~ p.154
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1,1-Diphenyl-2-picrylhydrazyl Radical Scavenging Compounds of Fraxini Cortex
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Kim Hyun-Chul
An Ren-Bo
Jeong Gil-Saeng
Oh Seung-Hwan
Kim Youn-Chul
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Abstract
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The radical scavenging effect of the MeOH extract of Fraxini Cortex on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical was examined. The CH2Cl2-and n-BuOH-soluble fractions of MeOH extract showed the promising DPPH radical scavenging effects, and further purified by silica gel, Sephadex LH-20 column chromatography, and reversed-phase C-18 MPLC to yield five coumarins, esculetin (1), fraxidin (2), fraxetin (3), fraxidin 8-O-β-D-glucopyranoside fraxin methyl ether) (5), esculin (6), and a secoiridoid oleuropein (4), and a coumarin-secoiridoid escuside (7). Compounds 1, 3, and 4 showed potent DPPH radical scavenging effects, exhibiting IC50 values of 14.68, 9.64, and 22.03μM, respectively. Compounds 6 and 7 also showed moderate effects with IC50 values of 147.79 and 72.73 μM, respectively. L-Ascorbic acid was used as a positive control and exhibited the IC50 value of 50.31μM
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KEYWORD
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Fraxini Cortex, Oleaceae, DPPH, Anti-radical, Coumarin, Oleuropein, Coumarin-secoiridoid
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