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KMID : 0620720050110030179
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Natural Product Sciences
2005 Volume.11 No. 3 p.179 ~ p.182
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Neuroprotective Effect of Acanthopanax sessiliflorus against Toxicity Induced by N-Methyl-D-Aspartate in Rat Organotypic Hippocampal Slice Culture
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Lee Pyeong-Jae
Lee Sang-Hyun
Choi Sang-Yoon
Son Dong-Wook
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Abstract
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We investigated that water extract of Acanthopanax sessiliflorus roots rescued the N-methyl-D-aspartate (NMDA), agonist of glutamate receptor, -induced toxicity in rat organotypic hippocampal slice culture. When the cell death in NMDA only-treated hippocampal slices was set 100%, A. sessiliflorus decreased the cell death to 75.4, 51.6, 48.9, and 40.6% at 1, 10, 50, and 100 ㎍/ml treatment, respectively. On the basis of these results, the water extract of A. sessiliflorus roots may be a preventive agent against NMDA-induced cytotoxicity.
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KEYWORD
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Acanthopanax sessiliflorus, Araliaceae, N-Methyl-D-Aspartate, Exicitoxicity, Hippocampal slice culture, Neuroprotection
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