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KMID : 0620720050110040199
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Natural Product Sciences
2005 Volume.11 No. 4 p.199 ~ p.206
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Phytochemical and Pharmacological Investigations on Moringa peregrina (Forssk) Fiori
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Elbatran Seham A.
Abdel-Salam Omar M.
Abdelshfeek Khaled A.
Nazif Naglaa M.
Ismail Shams I.
Hammouda Faiza M.
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Abstract
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Investigation of M. peregrina aerial parts revealed the isolation and identification of 4-flavonoidal compounds, quercetin, quercetin-3-0-rutinoside (rutin), chrysoeriol-7-0-rhamnoside 6,8,3’,5’-tetramethoxy apigenin. The compounds were identified by TLC, PC, MS, and H¹-NMR. The fatty acids and unsaponifiable matter were studied. The LD50 for M. peregrina was 113.4 mg/100g b.wt. Repeated intraperitoneal injection of 1/20 and 1/10 LD50 (5.67 mg and 11.34 mg/100g b.wt.) of defatted alcoholic of M. peregrina for 30 days induced significant decrease in serum glucose, liver enzymes and lipid components. M. peregrina administered i.p., 30min prior to carrageenan at the above doses significantly inhibited the rat paw oedema response, In acute pain models, namely, the acetic acid-induced writing and hot-plate assay, M. peregrina exhibited marked analgesic properties. In addition, M. peregrina administered at time of indomethacin injection inhibited the development of gastric lesions in rats.
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KEYWORD
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Moringa peregrina, Moringaceae, flavonoids, anti-diabetic, anti-oxidant, anti-inflammatory, analgesic
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