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KMID : 0620720050110040233
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Natural Product Sciences
2005 Volume.11 No. 4 p.233 ~ p.239
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Flavonoids of Gomphocarpus sinaicus and Evaluation of Some Pharmacological Activities
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Batran Seham A. El
Abdel-Azim Nahla S.
Abdel-Shafeek Khaled A.
Shahat Abd-Elatty A.
El-Missiry Moustafa M.
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Abstract
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The aerial parts of Gomphocarpus sinaicus Boiss. yielded four flavonoids that were identified as isorhamnetin 3-O-rhamnoglucoside (1), luteolin-7-O-glucoside-3-O-rhamnoside (2), rutin (3) and rutin-7-O-rhamnoside (4). All of the isolated flavonoids were identified by spectroscopic methods (UV, FAB-MS ¹H-NMR & ¹³C-NMR) and in comparison with the literature data. The isolated flavonoids 1, 2 and 4 are reported here for the first time from Gomphocarpus sinaicus Boiss. Three sets of experiments were carried out using the defatted alcoholic extract of Gomphocarpus sinaicus Boiss: the 1st experiment indicated that the LD50 was 49.82 mg/100 g b.wt. of intraperitoneally (i.p.) injected mice. The toxic signs were recorded within the first 24 hr post-injection. The 2nd experiment revealed that the extract of the plant exhibited significant anti-inflammatory effects in normal rats. The 3rd experiment was found that the tested doses of the extract in diabetic rats induced a significant decrease in serum glucose, AST, ALT, triglycerides, cholesterol and LDL, while HDL caused a significant increase.
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KEYWORD
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Gomphocarpus sinaicus Boiss., Asclepiadaceae, flavonoids, carrageenan, indomethacin, streptozotocin
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