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KMID : 0620720060120020074
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Natural Product Sciences
2006 Volume.12 No. 2 p.74 ~ p.78
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Studies on the Anti-Inflammatory and Analgesic Effects of Extracts from Marine Sponges
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Fakhr Issa M.I.
Hamdy Nehal A.
Radwan Mohamed A.A.
El-Batran Seham A.
Shabrawy Osama A. El
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Abstract
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Two specimens of sponges collected from Red Sea, Egypt, were investigated for their contents of secondary metabolites. The crude extracts of the sponges were tested for their anti-inflammatory and analgesic effects. The toxic effects of the extracts of the two marine sponges were studied LD50 determination revealed that the investigated extracts of ’Igernella and Ircinia spp’ were 4.69 and 134.7 mg/l00 g b.wt., respectively, when injected intraperitoneally in mice. The toxic signs were recorded within the first 24 hrs after injection. Also the two marine sponges extracts showed significant anti-inflammatory and analgesic effects.
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KEYWORD
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anti-inflammatory, analgesic, sponges, Igernella, Ircinia
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