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KMID : 0620720060120030134
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Natural Product Sciences
2006 Volume.12 No. 3 p.134 ~ p.137
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Gomisin J with Protective Effect Against t-BHP-Induced Oxidative Damage in HT22 Cells from Schizandra chinensis
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An Ren-Bo
Oh Seung-Hwan
Jeong Gil-Saeng
Kim Youn-Chul
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Abstract
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Four lignan compounds including gomisin J (1), schizandrin (2), gomisin A (3), and angeloyl gomisin H (4) have been isolated from the MeOH extract of Schizandra chinensis fruits. The evaluation for protective effect of compounds 1-4 against tert-butyl hydroperoxide (t-BHP)-induced cytotoxicity in hippocampal HT22 cell line was conducted. Compound 1 showed significant protective effect with an ECso value of 43.3±2.3 μM, whereas compounds 2-4 were inactive. Trolox, one of the well-known antioxidant, used as a positive control, and also showed protective effect with an ECso value of 21.3±8.4 μM. These results suggest that compound 1 may possess the neuroprotective activity against oxidant-induced cellular injuries.
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KEYWORD
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gomisin J, Schizandra chinensis, t-BHP-induced cytotoxicity, HT22 cells
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