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KMID : 0620720060120030157
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Natural Product Sciences
2006 Volume.12 No. 3 p.157 ~ p.161
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Screening of Momordica dioica for Hepatoprotective, Antioxidant, and Antiinflammatory Activities
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Shreedhara C.S.
Vaidya V.P.
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Abstract
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The alcoholic extract of Momordica dioica roots significantly reduced CCl₄induced hepatotoxicity in rats upon oral administration (200 mg/kg), as judged from the serum enzyme levels [serum glutamate oxaloacetate transaminases (SGOT), serum glutamate pyruvate transminases (SGPT), and alkaline phosphatase (ALP)]. These results were comparable with sylimarin (1.25 mg/kg, p.o.). The alcoholic extract inhibited the formation of oxyten derived free radicals (ODFR) in vitro with 4000μg/ml ascorbic system. The alcoholic extract also significantly reduced carrageenan-induced paw edema when administered orally (200 mg/kg) and the activity was comparable with ibuprofen(200 mg/kg, p.o.).
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KEYWORD
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Momordica dioica, hepatoprotective activity, antioxidant activity, antiinflammatory activity, plethysmometer, carrageenan
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