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KMID : 0620720060120040205
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Natural Product Sciences
2006 Volume.12 No. 4 p.205 ~ p.209
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Revision of Structures of Flavanoids from Scutellaria indica and Their Protein Tyrosine Phosphatase 1B Inhibitory Activity
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Min Byung-Sun
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Abstract
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The structures of flavonoids, 2(S)-5,7-dihydroxy-8,2’-dimethoxyflavanone (1), wogonin (2), 2(S)-5,7, 2’-trihydroxy-8-methoxyflavanone (3), and 2(S)-5,2’,5’-trihydroxy-7,8-dimethoxyflavanone (4), isolated from Scutellaria indica were revised on the basis of 2D NMR spectroscopy, including to gCOSY, gHSQC, and gHMBC. Compounds 1-4 were tested in vitro protein tyrosine phosphatase 1B (PTP1B) inhibitory activity. Compounds 2 and 4 exhibited weak PTP1B inhibitory activity with ICso values of 208 and 337㎛, respectively.
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KEYWORD
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Scutellaria indica, flavonoid, revision of structure, PTP1B
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